What is the Dopamine Hypothesis of Schizophrenia?

The dopamine hypothesis of schizophrenia states that symptoms may be caused by an excess of dopamine in the mid-brain and a reduction in dopamine in the prefrontal cortex. This hypothesis came from the finding that drugs that block dopamine (dopamine antagonists, such as antipsychotics) reduce the positive symptoms of schziphrenia. Additionally, drugs used to treat Parkinson's disease (that increase dopamine, such as L-DOPA) can have the side effect of producing psychosis-like symptoms.

This hypothesis has been supported not only by drug therapies but through post-mortem and brain imaging studies that report excess D2 receptors in the brains of people with schizophrenia.However, the relationship between dopamine and schizophrenia is merely correlational therefore we cannot determine causality, it is over simplistic as we know other neurotransmitters such as serotonin play a role and this is not considered and therefore this hypothesis may be criticised as being reductionist. Despite this it has useful applications and is perhaps one of the oldest and most widely supported hypothesis of schizophrenia.

Answered by Rosie M. Psychology tutor

10021 Views

See similar Psychology A Level tutors

Related Psychology A Level answers

All answers ▸

What is a type 1 error? Explain why psychologists use the significance level of 0.05 in research (3 marks)


Describe the elements of the cognitive interview (6 marks)


What are the three most common types of experimental design?


What is a case study and why might a psychologist choose to use this research method?


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

© MyTutorWeb Ltd 2013–2025

Terms & Conditions|Privacy Policy
Cookie Preferences