times both sides by both denominators
= (2x+3)(2x+1) - (2x-8)(x-4) = (2x+1)(x-4)
times out brackets
= (4x2 + 8x +3) - (2x2 -16x +32) = 2x2 -7x -4
simplify
= 2x2 +24x -29 = 2x2 -7x -4
bring x's to one side
= 31x = 25
solve for x
x= 25/31
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