How does Acetylcholine act on a neuronal synapse, and how is it re-uptaken?

 - Ca2+ voltage gated channels are activated due to an action potential reaching the synapse

 - Acetylcholine rests in the pre-synaptic cleft

 - They are stored in vesicles

 - The calcium influx causes the vesicles to move and fuse with the pre-synaptic membrane

 - They release their contents (Ach) into the synaptic cleft through diffustion through a channel

 - Ach binds to neuroreceptors on the post synaptic cleft, causing the channels to open and depolarisation to occur in the postsynaptic cleft

 - Excess Ach in the synaptic cleft is broken down by acetylcholinesterase to form Acetate & Choline

 - Choline is transported back into the axon terminal and is used to produce more Ach in the presynaptic neurone.

Answered by Krishan R. Biology tutor

1893 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

How do cells become specialized?


How do the components of a plasma membrane affect the movement of substances into and out of a cell, and why is this regulation important?


How does sexual selection lead to the evolution of elaborate male traits?


What is the cAMP cascade and where does it occur?


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

© MyTutorWeb Ltd 2013–2024

Terms & Conditions|Privacy Policy
Cookie Preferences