How does synaptic transmission across a neuromuscular junction work?

In order to answer the question, it is important to understand the terminology used. The neuromuscular junction refers to the communication between a neuron (neuro) and muscle cell (muscular). There are many neuromuscular junctions throughout the muscle, and they are required for simultaneous muscle contraction. The synapse is the space between the neuron and muscle cell, with the presynaptic membrane being the part of the neuron that faces the synapse and the post synaptic neuron being the part of the muscle cell that faces the synapse. Now to address the question asked, as the nerve impulse travels down the neuron it causes an influx of calcium ions into the neuron. This causes the synaptic vesicles to fuse with the presynaptic membrane. The vesicles contain a neurotransmitter called acetylcholine which diffuses across the synapse and stimulates the post synaptic membrane to allow sodium ions to enter the muscle cell, this results in muscle cell depolarization resulting in muscle contraction. The acetylcholine is then broken down by an enzyme called acetylcholinesterase, and then diffuses back into the presynaptic neuron.

Answered by Ellie T. Biology tutor

7711 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

a) Name a hormone secreted by the ovaries (1 mark). b) A female takes a contraceptive pill that increases the body's levels of progesterone. Explain what effects this has on the female's body and what effects that it has on her other hormones (3 marks)


I struggle with exam timing and as a result I always run out of time before finishing the paper. How can avoid this in the future?


What are phagocytes and how do they protect the body?


Describe the stages of Transcription


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

© MyTutorWeb Ltd 2013–2025

Terms & Conditions|Privacy Policy
Cookie Preferences