How does synaptic transmission across a neuromuscular junction work?

In order to answer the question, it is important to understand the terminology used. The neuromuscular junction refers to the communication between a neuron (neuro) and muscle cell (muscular). There are many neuromuscular junctions throughout the muscle, and they are required for simultaneous muscle contraction. The synapse is the space between the neuron and muscle cell, with the presynaptic membrane being the part of the neuron that faces the synapse and the post synaptic neuron being the part of the muscle cell that faces the synapse. Now to address the question asked, as the nerve impulse travels down the neuron it causes an influx of calcium ions into the neuron. This causes the synaptic vesicles to fuse with the presynaptic membrane. The vesicles contain a neurotransmitter called acetylcholine which diffuses across the synapse and stimulates the post synaptic membrane to allow sodium ions to enter the muscle cell, this results in muscle cell depolarization resulting in muscle contraction. The acetylcholine is then broken down by an enzyme called acetylcholinesterase, and then diffuses back into the presynaptic neuron.

Answered by Ellie T. Biology tutor

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