How are nerve impulses transmitted across a synapse?

Nerve impulses travel in one direction from the pre-synaptic to the post-synaptic neuron across a gap called a synapse. This is done to continue a nerve impulse so that it can reach its destination in the body. The process requires the use of a neurotransmitter, one of the most common is acetylcholine (ACh). Firstly the action potential reaches the synaptic cleft (end of the neuron) in the pre-synaptic neuron, causing the opening of voltage-gated calcium channels. Therefore, there is an influx of calcium into the axon causing vesicles containing ACh to fuse with the synaptic membrane and release ACh. This ACh then diffuses from a high to low concentration towards the post-synaptic neuron and binds with nicotinic ACh receptors. The binding causes the opening of ligand-gated sodium channels and therefore an influx of sodium into the post-synaptic axon to continue the impulse. Following this, ACh is broken down by acetylcholinesterase into acetyl and choline which both diffuse back to the pre-synaptic neuron ready to transmit future impulses.

EH
Answered by Elizabeth H. Biology tutor

7859 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

What are the 5 conditions for the Hardy Weinburg equiliberium? And if all of these conditions are met what does the equiliberium state?


How are polynucleotide DNA strands held together? (3 marks)


State the differences between introns and exons.


Explain the difference between the light dependent and light independent reactions of photosynthesis (2 marks).


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2025 by IXL Learning