How can donepezil improve communication between nerve cells?

Donepezil is an inhibitor of the enzyme acetylcholinesterase.
Acetylcholine is a neurotransmitter that diffuses across synapses, binds to the acetylcholine receptor and causes sodium ion channels to open. Influx of sodium ions into the neurone causes a new nerve impulse to be released.In normal cells, acetylcholinesterase breaks down acetylcholine to end the signal.
In diseased cells, there are problems with communication between neurones. Because Donepezil inhibits acetylcholinesterase, less acetylcholine is broken down, so more acetylcholine is available to bind to receptors, meaning more sodium ions enter neurons to reach the threshold for an action potential. 

Answered by Sarah W. Biology tutor

5299 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Some phenotypes, such as colour-blindness, are caused by sex-linked genes. Explain why colour-blindness is more common in men than in women


How is tissue fluid formed and returned to the circulatory system?


Describe the process of DNA replication.


Describe the process of transcription.


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

© MyTutorWeb Ltd 2013–2025

Terms & Conditions|Privacy Policy
Cookie Preferences