When high levels of glucose are detected in the blood, for example after a big meal, insulin is released from beta cells in the Islet of Langerhans. These are clusters of cells present in the pancreas.
Insulin acts on the liver to inhibit glucose production and promote the conversion of glucose to glycogen. Glycogen can then be stored in the liver. Insulin also binds to muscle or fat cells to stimulate the uptake of glucose into these cells. In combination, these processes help to lower the concentration of glucose in the blood back to normal.