In person A, once the glucose enters the blood stream, the higher glucose level is detected by the beta cells of the islets of Langerhans in the pancreas. These cells respond by synthesising insulin and secreting it into the blood, which interacts with receptors on the body's cells to cause uptake of glucose and synthesis of glycogen and fatty acids from the glucose taken up. This means that the blood glucose levels in person A rise and then quickly decrease again. Once the glucose levels decrease, the insulin levels also decrease.In person B, the beta cells in the pancreas have been damaged due to earlier autoimmune responses, and so much less insulin is secreted into the blood. This causes glucose to remain in Person's B's blood, and may result in hyperglycemia. If glucose levels are high enough, the glucose may be excreted via the kidneys.