Explain how a substitution mutation could cause an enzyme not to work (5)
The mutation changes the order of bases so there is a different triplet code present. This results in a different amino acid being coded for in the polypeptide chain. This means a different protein with a different tertiary structure is made. The enzymes active site will also be different and no longer complimentary to the substrate. Therefore no reaction can make place as the substrate can not fit into the enzymes active site any more.
EC
Related Biology GCSE answers
All answers ▸Megapode birds open and close the air vents of the nest at different times of the day. Suggest reasons why it is necessary to open and close the air vents.
What organelles are found in plant cells, but not in animal cells? What are the functions of these organelles?
Explain how the liver aids digestion in the alimentary canal
What is Lamarck's theory?