Haemophilia is a disease that affects blood clotting. People with haemophilia are sometimes given a protein called factor VIII. Factor VIII is an enzyme that is involved in the process of blood clotting. Explain how a change in the primary structure of f

A protein is made up of amino acid subunits, in which the primary structure is the sequence of the amino acids. Therefore a change in the primary structure will result in a different sequence of amino acids.This will in turn result in a change in R groups which will go on to affect the bonding (such as H bonds or ionic bonds) changing the resulting secondary or tertiary structure of the protein.This will result in a change in the active site and the substrate will no longer be able to bind, stopping the production of fibrin which will go on to affect the whole blood clotting cascade.