The macrophage engulfs the virus and the phagosome fuses with a lysosome, the virus is then broken down by hydrolytic enzymes inside the lysosome, and virus' antigens are displayed on the cell surface membrane. A helper T cell then binds to the antigen on the antigen-presenting cell, which stimulates a highly specific B cell which is complementary to this antigen on the antigen-presenting cell and this B cell then clones, and these B cells secrete the antibody.