If a gene mutation is associated with the development of Alzheimer's Disease (e.g. E280A), how might a high frequency develop in a population and why wouldn't natural selection decrease it?

A high frequency of mutation can be produced by having a small population, leading to high levels of inbreeding. When there is little interbreeding with different populations, the genetic diversity will remain low and the gene will become more prevalent within the population as it is passed from generation to generation, through various families sharing common ancestry. As Alzheimer's Disease doesn't develop until later in adulthood, survival to reproductive age is not affected. Thus, those affected will already have reproduced before disease onset and the gene mutation will be able to be passed down the generations without being reduced by natural selection.

Answered by Caitlin R. Biology tutor

2029 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

What is the function of coronary arteries?


Explain how you would test for the presence of lipids and proteins in an unknown solution. Give details on any observations you would expect to make.


Describe the process of DNA replication in eukaryotic cells.


Maltose is hydrolysed by the enzyme maltase. Explain why maltase catalyses only this reaction.


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo
Cookie Preferences