This question is on the trickier side as it is heavily computational and requires a good knowledge of the differentiation rules however it is a good way to practise using multiple rules at once.First we will use the quotient rule formula: dy/dx = [vdu-udv]/[v2]we will set: u = xcos(x3) and v = (x4+1)3by using the product and chain rule we can the calculate du = cos(x3) - 3x3sin(x3) and dv = 12x3(x4 + 1)2substituting these values into the quotient rule formula we get: dy/dx = { (x4 + 1)3[cos(x3) - 3x3sin(x3)] - 12x4cos(x3)(x4 + 1)2 }/{(x4 + 1)6}Finally, after simplifying we achieve: dy/dx = { cos(x3)(1 - 11x4) - 3x2sin(x3)(1 + x5) }/{(x4 + 1)4}