Generally a prokaryote is smaller, reaching roughly up to 5μm while eukaryotes are larger reaching roughly up to 100μm.
Eukaryotes have 80s ribosomes but prokaryotes have 70s ribosomes.
A eukaryotic cell contains membrane bound organelles due to compartimentilisation, this includes a membrane bound nucleus. A prokaryotic cells has no membrane bound oraganelles and no nucleus.
Prokaryotes have naked DNA in the form of a plasmid while eukaryotes have protein bound DNA.
A prokaryote reproduces by binary fission while eukaryotes use mitosis and meiosis.