Loneliness is a common theme throughout 'Of Mice and Men' arguably due to the harsh environment in which they live and work. George and Lennie’s friendship is a rare occurrence, and stands out as such within the book. This friendship is contrasting to many of the other characters within the book, who are often portrayed as isolated and lonely. Their relationship emphasises the need for a companion. Other examples of loneliness can be seen in Crooks' character, which is mainly due to his race. Curley's wife is isolated due to her gender. These intersectional themes can highlight key issues relating to a characters loneliness, and can help to answer the example question. The ruin of George and Lennie's dream at the end of the book demonstrates the impossibility of escaping the isolation caused by the conditions of the world that these men live.