To identify the structural differences between these two molecules, its helpful to understand their roles in the building of a protein. (translation and transcription)Their roles give clues to the overall structures they have, for example, messenger mRNA provides the coded message for proteins, in the form of a long chain of nucleotide bases. It is linear in structure. Contrastingly the transfer RNA must bring single amino acids to the ribosome as the protein builds. It therefore has a cloverleaf structure with a single binding site, which allows it to bind to one single amino acid, that later can be transfered as a protein is built.Another difference is between what the bases code for. Remember that both RNA molecules are made from nucleotide bases with Ribonucleic Acid. The bases, in triplets code to aminoacids, and so each triplet on mRNA is a codon. The triplets on the activebinding site that tRNA has, are opposite codes called anticodons. Therefore a key difference is that mRNA has codons, while each tRNA has an anticodon.