ADH (anti-diuretic hormone) is released by the pituitary gland in the brain. Differing amounts of ADH are secreted by the pituitary gland depending on the concentration of water in the blood plasma, which is detected by the hypothalamus in the brain.
For example, if the hypothalamus detects too much water in the blood:Less ADH is secreted by the pituitary gland.Less water is reabsorbed by the kidneys and more water is lost in urine.As a result of this, water levels return to normal. This is called a negative feedback loop.