blood sugar concentration is controlled through a negative feedback loop*. When blood glucose concentration is high, insulin made in the pancreas is released into the bloodstream. Glucose is taken into cells and converted into glycogen by the liver as a result. If blood glucose concentration falls, glucagon made in the pancreas is released from it, and converts glycogen into glucose. This glucose travels to the bloodstream increasing blood sugar concentration*a system where fluctuations above the optimal value or 'set point' are reduced. it is associated with a decrease in function.