What is it?Anti-diuretic hormone (ADH) is a hormone produced by the hypothalamus and released by the posterior pituitary gland (in the brain), that acts on the nephron in the kidney, specifically the distal convoluted tubule (DCT) and the collecting duct. Effects:It stimulates the cells of these parts of the nephron to put more water channels called aquaporins into their plasma membranes on the luminal side - the side that faces into the tubule. They make the membrane more permeable to water, but not to any ions. Therefore, more water is reabsorbed into the tubule cells and will be taken up into the blood.Purpose: If you are dehydrated, you need to as much water as possible in your blood, to prevent the ion concentrations from getting dangerously high and disturbing the balance of osmosis in the body. Receptors in the hypothalamus detect if this is beginning to happen and stimulate the release of ADH.