Bandits: Being in a largely lawless region of the country, settlers had to fend for themselves most of the time. A mixture of Indian and American raiders meant that the settlers were never truly safe, and the lack of a quick-response police force only made this worse.Isolation: Being so far away from the rest of society, often only having a couple neighbours within many miles of your home, life was difficult. If someone got sick, or hurt, or if they needed help from the rest of society, they would have to travel a long way to get it, and it was unreliable and dangerous. Supplies: The land settlers farmed was often hard to farm. Settlers struggled to produce food self sufficiently, without back-breaking work, and to farm such difficult land required tools and machinery. However, this machinery was difficult to get a hold of, since settlers were so isolated, and far from society.One can link these three points together if they want, it will make the argument look more connected, and show confidence in your points.