Replication- Porkaryotes undergo binary fission, whereas eukaryotes undergo mitosis/meiosisOrganelle- Prokaryotes have no membrane bound organelle. Ribosomes in prokaryotes are 70S and 80S in eukaryotes. DNA- the DNA in prokaryotes is naked and circular, whereas it is linear and associated with proteins in eukaryotes. Size- eukaryotes are larger than prokaryotes