This can be debated, however, I think it's the trade embargo that was placed upon Antwerp in 1493. This was done because Henry felt as thought dynasty was being threatened (an important theme in his foreign policy) by Margaret of Burgundy who was harbouring the pretender Warbeck, which was condoned by the Holy Roman Emperor Maximilian I. The embargo actually damaged English interests of merchants and producers of wool and cloth as Antwerp was a trading point from which England could trade with the rest of the continent. (Coleman called it the commercial metropolis of Europe). Eventually trade was restored in 1496 under Magnus Intercursus which also protected England from Margaret harbouring Warbeck.